By Dale J. Benos (Eds.)
Sodium reabsorbing epithelia play a huge position in whole-body sodium homeostasis. a few examples of sodium regulating tissues contain kidney, colon, lung, and sweat ducts. Sodium shipping throughout those membranes is a two-step procedure: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for shipping and are regulated through a number of assorted hormones. The sodium channels additionally play an important position in a couple of affliction states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful range presents the 1st in-depth alternate of principles touching on those sodium channels, their rules and involvement in general and pathophysiological occasions. Key beneficial properties * Summarizes present country of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal rules of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * offers principles on sodium channels and ailment
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Additional info for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity
The utility of the planar lipid bilayer technique resides in the opportunity it provides to study channel activity in biophysical terms in the absence of a complicating and sometimes confounding cell 1. Structure/Function in abENaC 21 system. Although the subtleties of channel gating, amiloride affinity, and ion selectivity may be hidden when investigating macroscopic cell function, the study of these parameters allows us to begin to focus on the individual amino acid residues that regulate channel and ultimately cellular behavior.
The current/voltage relations for wt abENaC and K504E and K515E abENaC are shown on the top panel. Neither mutation affected single-channel conductance recorded under symmetrical conditions. The ion selectivity of wild-type and mutant ENaC subunits was determined under bi-ionic conditions, with 100 mM Na+ in the trans compartment and 100 mM K+ in the cis chamber, and is shown in the bottom panel. Values are mean t SD for 4 to 7 experiments at each voltage, as calculated from events histogram analysis.
Sorscher, E. , Brinkley, B. , and Benos, D. J. (1989). Immunochemical localization of amiloride-sensitive sodium channels in sodium transporting epithelia. J. Cell Sci. 93, 349-362. , and Lazdunski, M. (1995a). Functional degenerin-containing chimeras identify residues essential for arniloride-sensitive Na+ channel function. J. Biol. Chem. 270,11735-1 1737. , and Lazdunski, M. (1995b). Molecular cloning and functional expression of a novel amiloride-sensitive Na’ channel. J. B i d . Chem. 270,27411-27414.